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Figure 7-16: Use the Dodge tool to lighten small areas 83 Index A Absolute risk, teratogenicity, 117 Absorption (toxicokinetics), 2834 animal tests, descriptive, 67 Henderson-Hasselbach equation, 3032 intestinal tract, lipidwater partition coefficients and, 37 in vitro ADME studies, 206207 ionic and non-ionic lost, 2830 in nasal and respiratory mucosa, 3233 transport of molecules, 3334 Absorption, distribution, metabolism, and elimination (ADME) studies, 28, 206207 Academic research, applications of toxicology, 5 Acceptable daily intake (ADI), developmental toxicity, 117 Accumulation, chronic toxicity, 9091 Acidbase characteristics Henderson-Hasselbach equation, 3032 ionic and non-ionic principles, 2930 plasma protein binding, 37 Actinic keratoses, 106 Active transport, 33 Activity, plasma protein binding and, 37 Acute effects delayed effects versus, 14 reversibility of, 14 Acute exposure exposure duration and frequency, 1819 subchronic, defined, 90 Acute lethality determination, LD50 tests, 8386 Acute toxic class method (ATCM), range-finding tests, 7778 Acute toxicity alternative methods for measurement, 284285 in vitro tests, 192200; see also Cell culture methods for acute toxicology testing dermal, 198200 ocular, 193198 in vivo tests dermal, 101107 ocular, 107108.
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